Georgia Institute of TechnologySchool of Chemical & Biomolecular Engineering
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Publications


Books

A.S. Bommarius and B.R. Riebel, “Biocatalysis – Fundamentals and Applications”, Wiley-VCH, 2004, ISBN: 3-527303-448
(Thank you to all our readers! We made the TopTen list of the most successful, non-textbook Wiley-VCH titles for 2004!)


Refereed Papers

  1. V. Yeh, J. M. Broering, A. Romanyuk, B. Chen, Y. O. Chernoff, A. S. Bommarius. The Hofmeister effect on amyloid formation using yeast prion protein, Protein Sci, in press.

  2. P. Bansal, M. Hall, M. J. Realff, J. H. Lee, A. S. Bommarius. Modeling Cellulase Kinetics on Lignocellulosic Substrates. Biotechnol. Adv. 2009, 27, 833-848.

  3. T. A. Rogers, R. M. Daniel, A. S. Bommarius, “Deactivation of TEM-1 b -lactamase investigated by isothermal batch and non-isothermal continuous enzyme membrane reactor methods”, ChemCatChem 2009, 1, 131-137.

  4. B.L.W. Loo, A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Analysis of recombinant sequences for interacting residues can improve the quality of combinatorial library: case study on fluorescent proteins”, Biotech. J. 2008, 3, 63-73

  5. A.S. Bommarius, Adrian Katona, Sean E. Cheben, Arpit S. Patel, Arthur J. Ragauskas, Kristina Knudson, and Yunqiao Pu, “Cellulase kinetics as a function of cellulose pretreatment”, Metab. Eng. 2008, 10, 370-381

  6. J.M. Broering and A.S. Bommarius, “A kinetic model for salt-induced protein deactivation”, J. Phys. Chem. B. 2008, 112, 12768–12775

  7. N. Kothari, A.A. Jafarpour, R.P. Trebino, T.L. Thaler, A.S. Bommarius, “Astrobiological polarimeter”, Astrobiology 2008, 8, 1061-1069.

  8. E. Vázquez-Figueroa, V. Yeh, J.M. Broering, J.F. Chaparro-Riggers, and A.S. Bommarius, “Thermostable Variants Constructed via the Structure-guided Consensus Method also Show Increased Stability in Salt Solutions and Homogeneous Aqueous-Organic Media”, Protein Eng. Des. Sel. 2008, 21, 673-680

  9. J.F. Chaparro-Riggers, K.M. Polizzi, E. Vazquez-Figueroa, T.A. Rogers, and A.S. Bommarius, “Comparison of three Enoate Reductases and their potential use for biotransformations”, Adv. Synth. Catal. 2007, 349, 1521-1531

  10. J.M. Broering and A.S. Bommarius, “Cation and strong cosolute effects on protein kinetic stability”, Biochem. Soc. Trans. 2007, 35, 1602-5.

  11. E. Vazquez-Figueroa, J.F. Chaparro-Riggers, and A.S. Bommarius, “Development of a Thermostable Glucose Dehydrogenase via a Structure-guided Consensus Concept”, ChemBioChem 2007, 8, 2295-2301.

  12. J.F. Chaparro-Riggers, B.L.W. Loo, K.M. Polizzi, P.R. Gibbs, X.-S. Tang, M.J. Nelson, and A.S. Bommarius, „Revealing Biases Inherent in Recombination Protocols“, BMC Biotechnology 2007, 7, 77

  13. E.M. Hill, J.M. Broering, J.P. Hallett, C.L. Liotta, C.A. Eckert, and A.S. Bommarius, “Coupling Chiral Homogeneous Biocatalysis with Benign Heterogeneous Separation”, Green Chemistry 2007, 9, 888-893

  14. K.M. Polizzi, D.A. Moore, and A.S. Bommarius, “A short-chain dehydrogenase/reductase from Vibrio vulnificus with both blue fluorescence and oxidoreductase activity”, Chem. Comm. 2007, 1843-5

  15. K.M. Polizzi, A.S. Bommarius, J.M. Broering, J.F. Chaparro-Riggers, “Stability of enzymes”, Curr. Opin. Chem. Biol. 2007, 11, 220-225

  16. J.F. Chaparro-Riggers, K.M. Polizzi, A.S. Bommarius, “Better library design: data-driven protein engineering”, Biotechnol. J. 2007, 2, 180-191

  17. T.L. Thaler, P.R. Gibbs, R.P. Trebino, and A.S. Bommarius, “Search for Extraterrestrial Life Using Chiral Molecules: Mandelate Racemase as a Test Case”, Astrobiology 2006, 6, 910-920

  18. A.S. Bommarius, J.M. Broering, J.F. Chaparro-Riggers and K.M. Polizzi, “High-Throughput Screening for enhanced stability of proteins” , Curr. Opin. Biotechnology 2006, 18, 606-610

  19. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Identifying the Interacting Positions of a Protein using Boolean learning and Support Vector Machines”, Comp. Biol. Chem. 2006, 30, 268-279

  20. G.T. Lountos, R. Jiang, W.B. Wellborn, T.L. Thaler, A.S. Bommarius and A.M. Orville, “The Crystal Structure of NAD(P)H Oxidase from Lactobacillus sanfranciscensis: Insights into the Conversion of O2 into Two Water Molecules by the Flavoenzyme“, Biochemistry 2006, 45, 9648-9659

  21. K.M. Polizzi, M. Parikh, C.U. Spencer, I. Matsumura, J.H. Lee, M.J. Realff, and A.S. Bommarius, “Pooling for Improved Screening of Combinatorial Libraries for Directed Evolution” , Biotechnol. Progr. 2006, 22, 961-967

  22. J.M. Broering, E.M. Hill, J.P. Hallett, C.L. Liotta, C.A. Eckert, and A.S. Bommarius, "Biocatalytic reaction and recycle using CO2-induced Organic Aqueous Tunable Solvents (OATS)", Angew. Chem. Intl. Ed. 2006, 45, 4670-4673

  23. K.M. Polizzi&, J.F. Chaparro-Riggers&, E. Vazquez-Figueroa, and A.S. Bommarius, “Structure-guided consensus approach to create a more thermostable penicillin G acylase”, Biotechnology J. 2006, 1, 531-536

  24. A.S. Bommarius and K.M. Polizzi, “Novel biocatalysts: recent developments”, Chem. Eng. Sci. 2006, 61, 1004-1016

  25. K.M. Polizzi, C.U. Spencer, A. Dubey, I. Matsumura, J.H. Lee, M.J. Realff, and A.S. Bommarius, “Simulation modeling of pooling for combinatorial protein engineering”, J. Biomol. Screening, 2005, 10, 856-864

  26. A.S. Bommarius and A. Karau, “Deactivation of formate dehydrogenase (FDH) in solution and at gas-liquid interfaces”, Biotechnol. Progr. 2005, 21, 1663-1672

  27. J.M. Broering and A.S. Bommarius, „Evaluation of Hofmeister effects on the kinetic stability of proteins“, J. Phys. Chem. B 2005, 109, 20612-19

  28. A.S. Bommarius and J.M. Broering, ““Established and novel tools to investigate biocatalyst stability”, Biocatalysis and Biotransformation 2005, 23, 125-139

  29. R. Jiang, B.R. Riebel and A.S. Bommarius, “Comparison of competing oxygen reduction pathways in Lactococcus lactis: four-electron vs. two-electron reduction by NADH oxidases”, Adv. Synth. Cat. 2005, 347, 1139-1146

  30. P.R. Gibbs, C.S. Uehara, U. Neunert, and A.S. Bommarius, “Accelerated biocatalyst stability testing for process optimization”, Biotech. Progr. 2005, 21, 762-774

  31. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Support Vector Machines for Predicting the Critical Positions of a Protein”, J. Theor. Biol. 2005, 234, 351-361

  32. G.T. Lountos, B.R. Riebel, W.B. Wellborn, A.S. Bommarius, A.M. Orville, "Crystallization and Preliminary Analysis of a Water-Forming NADH Oxidase from Lactobacillus sanfranciscensis", Acta Cryst. D, 2004, 60, 2044-47

  33. R. Jiang and A.S. Bommarius, "Hydrogen peroxide-producing NADH oxidase (nox 1) from Lactococcus lactis", Tetrah. Asymm. 2004, 15, 2939-44

  34. P. Ödman, W.B. Wellborn, A.S. Bommarius, "An enzymatic process to -ketoglutarate from L-glutamate: the coupled system L-glutamate dehydrogenase/NADH oxidase", Tetrah. Asymm. 2004, 15, 2933-37

  35. J. Lu, M.J. Lazzaroni, J.P. Hallett, A.S. Bommarius, C.L. Liotta, and C.A. Eckert, "Tunable Solutions for Homogeneous Catalyst Recycle", I&EC Research 2004, 43, 1586-1590

  36. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of both NAD+ from NADH and NADP+ from NADPH: NADH oxidase from Lactobacillus sanfranciscensis", Adv. Synth. Cat., 2003, 345, 707-712

  37. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of NAD+ from NADH: novel water-forming NADH oxidases", Adv. Synth. Cat., 2002, 344, 1156-1169

  38. O. May, S. Verseck, A.S. Bommarius, and K. Drauz, "Development of Dynamic Kinetic Resolution Processes for Biocatalytic Production of Natural and Nonnatural L-Amino Acids", Organic Process Research & Development. 2002, 6, 452-457

  39. J. Wöltinger, K. Drauz and A. S. Bommarius, "The Membrane Reactor in the Fine Chemicals Industry", Appl. Catalysis A: General. 2001, 221, 171–185

  40. S. Verseck, A.S. Bommarius and M.-R. Kula, "Screening, Overexpression and Characterization of an N-Acylamino Acid Racemase from Amycolatopsis orientalis subsp. lurida", Appl. Microbiol. Biotechnol. 2001, 55, 354-361

  41. A.S. Bommarius, M. Schwarm and K. Drauz, "Comparison of Different Chemoenzymatic Process Routes to Enantiomerically Pure Amino Acids", Chimia 2001, 55, 50-59

  42. J. Wöltinger, H. Henniges, A.S. Bommarius, H.-P. Krimmer and K. Drauz, "Application of the continuous Sharpless-dihydroxylation", Tetrahedron Asymmetry 2001, 12, 2095-2098

  43. J. Wöltinger, A.S. Bommarius, K. Drauz and C. Wandrey, "The Chemzyme Membrane Reactor in the Fine Chemicals Industry", Organic Process Research & Development, 2001, 5, 241-248

  44. A.S. Bommarius, K. Drauz, S. Eils, J. Kirchhoff and M. Schwarm, "Reduction Technologies in the Industrial Synthesis of Fine Chemicals", Chimica Oggi 2000, 18, 12-17

  45. A.S. Bommarius, M. Schwarm and K. Drauz, "Biocatalysis to Amino Acid-based Chiral Pharmaceuticals - Examples and Perspectives", J. Mol. Cat B: Enzymatic 1998, 5, 1-11

  46. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Synthesis of dipeptides by suspension-to-suspension conversion via thermolysin catalysis - from analytical to preparative scale", J. Peptide Science 1997, 3, 245-251

  47. G. Krix, A.S. Bommarius, K. Drauz, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Enzymatic reduction of a-keto acids leading to L-amino acids or D-hydroxy Acids", J. Biotechnology 1997, 53, 29-39;

  48. A.S. Bommarius, K. Drauz, K. Günther, G. Knaup and M. Schwarm, "L-Methionine Related L-Amino Acids by Acylase Cleavage of Their Corresponding N-Acetyl-DL-Derivatives", Tetrahedron Asymmetry 1997, 8, 3197-3200

  49. U. Stelkes-Ritter, G. Beckers, A.S. Bommarius, K. Drauz, K. Günther, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Kinetics of peptide amidase and its application for the resolution of racemates", Biocatalysis and Biotransformations 1997, 15, 205-219

  50. A.S. Bommarius, M. Schwarm and K. Drauz, "The membrane reactor for the acylase process - from laboratory results to commercial scale", Chimica Oggi 1996, 14(10), 61-64;

  51. A.S. Bommarius, D.I.C. Wang and T.A. Hatton, "Xanthine Oxidase Reactivity in Reversed Micellar Systems: A Contribution to the Prediction of Enzymatic Activity in Organized Media", J. Amer. Chem. Soc. 1995, 117, 4515-4523;

  52. U. Joeres, A.S. Bommarius, J. Thömmes & M.-R. Kula, "Studies on the kinetics and application of L-carnitine amidase for production of L-carnitine", Biocatalysis & Biotransformation 1995, 12, 27-36;

  53. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Environmentally acceptable synthesis of peptides in high yields by suspension-to-suspension conversion via protease catalysis", PEPTIDES 1994, (Hrsg.: H.L.S. Maia), Escom, Leiden, 1995, 226-7;

  54. T.A. Hatton and A.S. Bommarius, "A population balance analysis of substrate distribution effects on enzymatic reaction rates in reversed micelles", Proceedings of the Material Research Society 1995, 366, 439-444;

  55. A.S. Bommarius, M. Schwarm, K. Stingl, M. Kottenhahn, K. Huthmacher and K. Drauz, "Synthesis and Use of Enantiomerically Pure tert.-Leucine", Tetrahedron Asymmetry 1995, 6, 2851-2888;

  56. A. Fischer, A.S. Bommarius, K. Drauz and C. Wandrey, "A novel approach to enzymatic peptide synthesis using highly solubilizing Na-protecting groups of amino acids", Biocatalysis 1994, 8, 289-307;

  57. A.S. Bommarius, K. Drauz, W. Hummel, M.-R. Kula and C. Wandrey, "Some new developments in reductive amination with cofactor regeneration", Biocatalysis 1994, 10, 37-47;

  58. A.S. Bommarius and K. Drauz, "An Enzymatic Route to L-Ornithine from Arginine - Activation, Selectivity and Stabilization of L-Arginase", Bioorganic and Medicinal Chemistry 1994, 2, 617-626;

  59. C. Petit, A.S. Bommarius, M.-P. Pileni and T.A. Hatton, "Characterization of a Four-Component Cationic Reversed Micellar System: DTAC/Hexanol/n-Heptane/0.1 M KCl Solution", J. Phys.Chem. 1992, 96, 4653-58;

  60. A.S. Bommarius, K. Drauz, H. Klenk und C. Wandrey, "Operational Stability of Enzymes - Acylase-Catalyzed Resolution of N-Acetyl Amino Acids to Enantiomerically Pure L-Amino Acids", Annals N.Y. Acad. Sci. (Enzyme Eng. XI) 1992, 672, 126-36;

  61. A.S. Bommarius, M. Kottenhahn, H. Klenk and K. Drauz, "A versatile direct route from hydantoins to D-amino acids employing a resting cell biocatalyst with D-hydantoinase and D-carbamoylase activity", in: "Microbial Reagents in Organic Synthesis", ed.: S. Servi, Kluwer Acad. Publ., Dordrecht, London, Boston, NATO ASI Series 1992, C 381, 161-174;

  62. E.B. Leodidis, A.S. Bommarius and T.A. Hatton, "Amino Acids in Reversed Micelles: Dependence of the Interfacial Partition Coefficient on Excess Phase Salinity and Interfacial Curvature", J. Phys. Chem. 1991, 95, 5943-56;

  63. A.S. Bommarius, K. Makryaleas & K. Drauz, "An Enzymatic Route to L-Ornithine from L-Arginine; Activation and Stabilization Studies on L-Arginase", Biomed. Biochim. Acta 1991, 50, 249-55

  64. A. Fischer, A. Schwarz, C. Wandrey, A.S. Bommarius, G. Knaup and K. Drauz, "Preparative-scale enzyme-catalyzed peptide synthesis using solubilizing N-terminal protecting groups", Biomed. Biochim. Acta 1991, 50, 169-74

  65. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang & T.A. Hatton, "Coalescence and Solubilizate Exchange in a Cationic Four Component Reversed Micellar System", J. Phys. Chem. 1990, 94, 7232-39

  66. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang and T.A. Hatton, "A Population Balance Model for the Determination of Solubilizate Exchange Rate Constants in Reversed Micellar Systems", in: "Structure, Dynamics, and Equilibrium Properties in Colloidal Systems", NATO ASI Series C 1990, 324, 181-99, eds.: H.B. Bloor & E. Wyn-Jones, Kluwer Acad. Publ., Dordrecht, London, Boston

  67. J.W. Shield, H.D. Ferguson, A.S. Bommarius and T.A. Hatton, "Enzymes in Reversed Micelles as Catalysts for Organic-Phase Reactions"; Ind. Eng. Chem. Fundam. 1986, 25, 603-612 trial