- Engineering non-pancreatic cells for glucose-responsive secretion of recombinant insulin with kinetics that closely approximate those of normal pancreatic islets.
- Developing methods for the low temperature preservation (cryopreservation) of encapsulated cells and other tissue engineered systems.
- Developing approaches for the non-invasive monitoring of tissue engineered substitutes in vitro and post-implantation in vivo.
- Engineering bioreactor systems for the functional maturation of islets and for the characterization of the metabolic and secretory competency of free and encapsulated cells.
B.S. 1979, National Technical Univ., Athens, Greece Ph.D. 1985, University of Minnesota